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KMID : 1037920230100010028
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Arthroscopy and Orthopedic Sports Medicine
2023 Volume.10 No. 1 p.28 ~ p.33
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Safety and effectiveness of arthroscopic-assisted implantation of allogenic umbilical cord blood-derived mesenchymal stem cells (Cartistem®)
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Cha Dong-Hyuk
Kim Dong-Hwi
Kook Jeong-Min
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Abstract
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Background: The purpose of this study was to investigate the safety and efficacy of arthroscopy-assisted implantation of Cartistem®, an articular cartilage regeneration treatment composed of allogeneic umbilical cord blood-derived mesen-chymal stem cells, during medial owHTO for KL grades II and III patients with medial compartment osteoarthritis of the knee joint; radiological and clinical.
Methods: From October 2017 to July 2019, arthroscopic chondroplasty with Cartistem® and medial owHTO were done on lesions with ICRS grade IV in patients with medial compartment arthritis and varus knee. Radiological outcomes including magnetic resonance imaging before and 1 year after surgery were used to calculate the extent of a chondral defect, KL grade, and joint space distance. Furthermore, the KSS and Lysholm score were calculated before and after sur-gery. The ICRS grade was determined at least 1 year following the operation through the second arthroscopy.
Results: Eight patients who were followed up on for more than 1 year and had the second arthroscopy were investigated retrospectively out of a total of 22 cases. In radiological comparison before and after surgery, the KL grade was improved from III to II in two patients. In 8 patients, the JSD improved dramatically from 3.75 mm to 4.63 mm. The anatomical femorotibial angle was adjusted from varus 2.46° to valgus 9.28°. In the clinical score of 8 patients, the KSS climbed from an average of 46.63 to 70.50 and the Lysholm score increased from an average of 43.5 to 75.5, showing a substantial differ-ence. Furthermore, all patients who underwent a second arthroscopy had a significant improvement in their ICRS grade.
Conclusion: For individuals with KL grade II and III and ICRS Grade IV medial compartment osteoarthritis of the knee, chondroplasty with Cartistem® under arthroscopy during medial owHTO can significantly improve the radiological and clinical outcomes.
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KEYWORD
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High tibial osteotomy, Arthroscopy, Chondroplasty, Cartistem
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